Mathematical liver modeling: hemodynamics and function in hepatectomy
vendredi 3 mars 2017, 11h00 - 12h00
Major liver resection is being performed to treat liver lesions or for adult-to-adult living donor liver transplantation. The links between liver hemodynamics, liver volume and liver function remain unclear and are important to better understand these surgeries complications. The surgery increases the resistance to blood flow in the organ, therefore it modifies liver hemodynamics. Large modifications of the portal vein hemodynamics have been associated with poor liver regeneration. Moreover the liver receives 25% of the cardiac outflow, therefore liver surgery may impact the whole blood circulation.
In this context, first we investigate, with a model of the global circulation, including 0D and 1D equations, the impact of the liver surgery on liver hemodynamics. Then, we study the liver perfusion and function with a pharmacokinetics model and its parameters identification to quantitatively analyze indocyanine green fluorescence dynamics in the liver tissue.