On mitochondria models: Analysis and Simulation
vendredi 24 juin 2011, 11h00 - 12h00
Résumé / Abstract :
We introduce an mathematical approach modeling the swelling of mitochondria. High Ca^2+-concentrations lead to permeabilization of the mitochondrial membranes accompanied by mitochondrial swelling. This is a decisive event in apoptosis or necrosis culminating in cell death. The swelling is measured by means of decreasing light scattering values at a fixed wave length. Our aim is to understand and describe the experimental results mathematically. The model gives insight into the swelling kinetics and shows the total volume changes of a mitochondrial population. It can be adapted to other inducing conditions or to mitochondria from other biological sources. To take into account the spatial dependence, we extend the ODE model and obtain a coupled ODE-PDE system.