Greedy search of interactions between genome and microbiome in association studies

vendredi 27 novembre 2015, 9h30 - 10h30

Salle de réunion, espace Turing

Association studies usually search for association between common genetic variants in different individuals and a given phenotype. In this work we do consider two types of human biological markers: genetic and human intestinal metagenomic markers. The genotypic markers allow to characterise the individual by its inherited genetic information whereas the metagenomic markers are related to the individuals environment since they are influenced by many environmental parameters (the most obvious being the individual dietary habits). Both types of markers are available by millions and represent a unique signature of each individual.

We propose to focus on the detection of interaction between groups of metagenomic and genetic markers in order to better understand the complex relationship existing between environment and genome in the expression of a given phenotype. The proposed is based on a greedy exploration of the interaction space and will be illustrated by means of simulation.