Rinaldo Schinazi (Colorado Springs)

A branching process for virus survival

vendredi 13 janvier 2012, 14h30 - 15h30

Salle de réunion, espace Turing

Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed. We propose a new branching model that shows that this is not necessarily so. That is, a population composed of ever changing mutants may survive.