Leonid Berlyand (Dept. of Mathematics & Materials Research Institute, Penn State University)

Phase Field and Free Boundary Models of Cell Motility

vendredi 9 juin 2017, 11h00 - 12h00

Salle du conseil, espace Turing

Abstract :

We study two types of models describing the motility of eukaryotic cells on substrates. The first, a phase-field model, consists of the Allen-Cahn equation for the scalar phase field function coupled with a vectorial parabolic equation for the orientation of the actin filament network.

The two key properties of this system are (i) presence of gradients in the coupling terms and (ii) mass (volume) preservation constraints. We pass to the sharp interface limit to derive the equation of the motion of the cell boundary, which is mean curvature motion modified by a novel nonlinear term. We establish the existence of two distinct regimes of the physical parameters and prove existence of traveling waves in the supercritical regime.

The second model type is a non-linear free boundary problem for a Keller-Segel type system of PDEs in 2D with area preservation and curvature entering the boundary conditions. We find an analytic one-parameter family of radially symmetric standing wave solutions (corresponding to a resting cell) as solutions to a Liouville type equation. Using topological tools, traveling wave solutions (describing steady motion) with non-circular shape are shown to bifurcate from the standing waves at a critical value of the parameter. Our bifurcation analysis explains, how varying a single (physical) parameter allows the cell to switch from rest to motion.

The work was done jointly with J. Fuhrmann, M. Potomkin, and V. Rybalko.